Amelioration of heart failure by MDL 17043 and MDL 19205, novel positive inotropic drugs, in dog heart-lung preparations.

A renaissance of positive inotropic interventions to treat heart failure?

̈ See article by Kogler et al. [1] (pages 582–592) in tion for terminal heart failure, the protein expression of XO this issue. was increased compared to control samples [3]. In isolated cardiac muscles from rat, allopurinol and oxypurinol 21 Heart failure has a high and increasing prevalence due to increased developed tension at constant intracellular Ca the aging population and the better surv...

A novel isolated dual perfusion/superfusion heart model for physiological and pharmacological evaluation of mammalian heart preparations

Abstract Introduction: Isolated perfused heart models such as perfusion and superfusion are commonly used for mammalian heart research. However, there are several fundamental limitations in the current techniques. In perfusion model, a suitable cannula is connected to the aorta and the perfusion is retrogradely performed. But, electrode displacement is a potential unwanted event resulted fr...

Home Inotropic Therapy in Advanced Heart Failure

Study objectives: This study was conducted to assess cost savings and clinical outcomes associated with the use of home IV inotropic therapy in patients with advanced (New York Heart Association [NYHA] class IV) heart failure. Design: Retrospective analysis. Setting: Tertiary care referral center. Patients and interventions: Twenty-four patients (13 men, 11 women; age, 61 ±12 years) with left v...

Inotropic therapy for heart failure: paradise lost.

The effort to demonstrate efficacy and safety of an oral phosphodiesterase III (PDE3)-inhibiting inotropic drug in patients with chronic heart failure has been long, arduous, and largely unsuccessful. 6 The persistence of the effort is based on the widely held perception that heart failure is precipitated and sustained by a left ventricular contractile deficit and that PDE3 inhibitors can corre...

The effect of inotropic drugs on filling of the isolated right ventricle of the dog heart.